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Advanced dementia, however, should be considered a terminal illness, and the goals of treatment should be to reduce physical discomfort and maintain well-being.

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Donepezil HCl (E2020) maintains functional brain activity in patients with Alzheimer disease: results of a 24-week, double-blind, placebo-controlled study.

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Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change.

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The primary outcome measure will be the rate of disease progression as measured by the ALS Functional Rating Scale- Revised (ALSFRS-R).

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Five treatment efficacy studies had quality scores ranging from 5 to 7 of 9 possible markers.

Non-cholinergic drug development for Alzheimer's disease.

However, the results do not provide any evidence that cognitive rehabilitation improves cognition, ADLs or when compared to an active control (mental stimulation).

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Copyright 2016 Truven Health Analytics, Inc.

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It has been found that patients with AD have a decreased volume of the hippocampus when compared to non-affected individuals, and patients with some degree of atrophy are more liable to develop AD.

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Some preliminary information on second-generation memantine derivatives, termed NitroMemantines, is also provided.

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The combination of Memantine and Donepezil is a currently used treatment option for patient suffering from AD.

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Neurological phenotypes associated with DS include increased incidence of seizure disorder in relation to the general population, motor and oculomotor dysfunction and a virtually universal incidence of a neuropathology indistinguishable from Alzheimer's disease (AD) by age 40 years.

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With no changes in SKT and KAI, psychometric testing showed no deterioration of in the treated participants.

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His laboratory receives NIH funding for a study unrelated to the current study.

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Randomized controlled trial of memantine in dementia associated with Parkinson's disease.

FDA approved memantine, an N-methyl-D-aspartate (NMDA) antagonist that reduces certain types of brain activity by binding to NMDA receptors and blocking the activity of glutamate, which in AD can overstimulate nerve cells and kill them.

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Determination of memantine in plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.

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